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lepA protein (Acidaminococcus intestini) - STRING interaction network
"lepA" - GTP-binding protein lepA in Acidaminococcus intestini
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lepAGTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (601 aa)    
Predicted Functional Partners:
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (128 aa)
 
 
  0.826
prfA
Peptide chain release factor; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (359 aa)
 
   
  0.824
pheS
phenylalanyl-tRNA synthetase subunit alpha (341 aa)
   
   
  0.756
leuS
leucyl-tRNA synthetase (830 aa)
 
   
  0.742
gidA
tRNA uridine 5-carboxymethylaminomethyl modification protein MnmG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (626 aa)
 
   
  0.698
aspS
aspartyl-tRNA synthetase (596 aa)
 
   
  0.690
dnaK
Chaperone dnaK; Acts as a chaperone (619 aa)
   
   
  0.687
rpsT
30S ribosomal protein S20; Binds directly to 16S ribosomal RNA (87 aa)
              0.680
rpsQ
30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5’-end of 16S ribosomal RNA (86 aa)
   
   
  0.658
guaA
Bifunctional GMP synthase/glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP (515 aa)
     
   
  0.647
Your Current Organism:
Acidaminococcus intestini
NCBI taxonomy Id: 568816
Other names: A. intestini, A. intestini RyC-MR95, Acidaminococcus intestini, Acidaminococcus intestini Jumas-Bilak et al. 2007, Acidaminococcus intestini RyC-MR95, Acidaminococcus intestini strain RyC-MR95, Acidaminococcus sp. ADV 255.99
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