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sbcD protein (Acidaminococcus intestini) - STRING interaction network
"sbcD" - Nuclease SbcCD subunit D in Acidaminococcus intestini
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sbcDNuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3’->5’ double strand exonuclease that can open hairpins. It also has a 5’ single-strand endonuclease activity (398 aa)    
Predicted Functional Partners:
Acin_1682
Uncharacterized protein; COG0419 (751 aa)
 
 
  0.995
cinA
Putative competence-damage inducible protein; COG1546; Belongs to the CinA family (413 aa)
         
  0.813
Acin_1322
annotation not available (158 aa)
   
 
  0.785
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (354 aa)
   
 
  0.710
recD
ATP-dependent RecD-like DNA helicase; DNA-dependent ATPase and ATP-dependent 5’-3’ DNA helicase. Has no activity on blunt DNA or DNA with 3’-overhangs, requires at least 10 bases of 5’-ssDNA for helicase activity (733 aa)
 
 
  0.672
Acin_1286
UvrD/REP helicase; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily (1110 aa)
         
  0.670
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (628 aa)
     
 
  0.643
Acin_1287
annotation not available (1032 aa)
         
  0.613
Acin_1680
annotation not available (165 aa)
              0.568
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (873 aa)
     
 
  0.548
Your Current Organism:
Acidaminococcus intestini
NCBI taxonomy Id: 568816
Other names: A. intestini RyC-MR95, Acidaminococcus intestini, Acidaminococcus intestini RyC-MR95, Acidaminococcus intestini strain RyC-MR95
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