STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (436 aa)    
Predicted Functional Partners:
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.991
purB
Adenylosuccinate lyase; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.989
purH
Bifunctional: IMP cyclohydrolase (N-terminal); COG0138.
  
 0.975
purL
Phosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.971
pyrB
Aspartate carbamoyltransferase, catalytic subunit; COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.937
asnB
Asparagine synthetase B; COG0367.
   
 
 0.934
aspC_1
Aspartate aminotransferase, PLP-dependent-1; COG1448.
  
 0.918
nadB
Quinolinate synthetase, B protein (L-aspartate oxidase); Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.911
aspA
Aspartate ammonia-lyase (aspartase); COG1027.
     
 0.902
thrA
Bifunctional: aspartokinase I (N-terminal); COG0460,COG0527; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.897
Your Current Organism:
Hamiltonella defensa
NCBI taxonomy Id: 572265
Other names: C. Hamiltonella defensa 5AT (Acyrthosiphon pisum), Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum), Candidatus Hamiltonella defensa str. 5AT (Acyrthosiphon pisum), Candidatus Hamiltonella defensa strain 5AT (Acyrthosiphon pisum)
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