node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HDEF_0489 | HDEF_0513 | HDEF_0489 | HDEF_0513 | Putative P-loop hydrolase; COG0802. | Putative peptidase, M22 family; COG1214. | 0.950 |
HDEF_0489 | tsaD | HDEF_0489 | HDEF_0458 | Putative P-loop hydrolase; COG0802. | O-sialoglycoprotein endopeptidase, Peptidase_M22 domain protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.858 |
HDEF_0513 | HDEF_0489 | HDEF_0513 | HDEF_0489 | Putative peptidase, M22 family; COG1214. | Putative P-loop hydrolase; COG0802. | 0.950 |
HDEF_0513 | tsaD | HDEF_0513 | HDEF_0458 | Putative peptidase, M22 family; COG1214. | O-sialoglycoprotein endopeptidase, Peptidase_M22 domain protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.979 |
aroB | topA | HDEF_1640 | HDEF_1767 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | DNA topoisomerase type I, omega protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, th [...] | 0.562 |
aroB | tsaD | HDEF_1640 | HDEF_0458 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | O-sialoglycoprotein endopeptidase, Peptidase_M22 domain protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.546 |
ksgA | leuS | HDEF_0775 | HDEF_2038 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.440 |
ksgA | lolD | HDEF_0775 | HDEF_0123 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind); Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. | 0.457 |
ksgA | pheS | HDEF_0775 | HDEF_1828 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Phenylalanine tRNA synthetase, alpha-subunit; COG0016; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.459 |
ksgA | pheT | HDEF_0775 | HDEF_1830 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Phenylalanine tRNA synthetase, beta-subunit; COG0072; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.668 |
ksgA | serS | HDEF_0775 | HDEF_1279 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Serine tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.560 |
ksgA | tsaD | HDEF_0775 | HDEF_0458 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | O-sialoglycoprotein endopeptidase, Peptidase_M22 domain protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.571 |
leuS | ksgA | HDEF_2038 | HDEF_0775 | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.440 |
leuS | pheS | HDEF_2038 | HDEF_1828 | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | Phenylalanine tRNA synthetase, alpha-subunit; COG0016; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.520 |
leuS | pheT | HDEF_2038 | HDEF_1830 | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | Phenylalanine tRNA synthetase, beta-subunit; COG0072; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.986 |
leuS | serS | HDEF_2038 | HDEF_1279 | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | Serine tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.757 |
leuS | topA | HDEF_2038 | HDEF_1767 | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA topoisomerase type I, omega protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, th [...] | 0.977 |
leuS | tsaD | HDEF_2038 | HDEF_0458 | Leucine tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | O-sialoglycoprotein endopeptidase, Peptidase_M22 domain protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.575 |
lolD | ksgA | HDEF_0123 | HDEF_0775 | Transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind); Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.457 |
lolD | pheS | HDEF_0123 | HDEF_1828 | Transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind); Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. | Phenylalanine tRNA synthetase, alpha-subunit; COG0016; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.474 |