node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ftsI | ftsL | HDEF_1789 | HDEF_1790 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.953 |
ftsI | ftsQ | HDEF_1789 | HDEF_1780 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.965 |
ftsI | ftsW | HDEF_1789 | HDEF_1784 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Essential cell division protein, stablilzes FtsZ ring, required for PBP2 expression; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.988 |
ftsI | mraW | HDEF_1789 | HDEF_1791 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | S-adenosyl-dependent methyl transferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.922 |
ftsI | mraZ | HDEF_1789 | HDEF_1792 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Cell division protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. | 0.834 |
ftsI | murC | HDEF_1789 | HDEF_1782 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme; Cell wall formation; Belongs to the MurCDEF family. | 0.948 |
ftsI | murD | HDEF_1789 | HDEF_1785 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.951 |
ftsI | murE | HDEF_1789 | HDEF_1788 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.988 |
ftsI | murF | HDEF_1789 | HDEF_1787 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | D-alanine:D-alanine-adding enzyme; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.958 |
ftsI | murG | HDEF_1789 | HDEF_1783 | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.977 |
ftsL | ftsI | HDEF_1790 | HDEF_1789 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.953 |
ftsL | ftsQ | HDEF_1790 | HDEF_1780 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.997 |
ftsL | ftsW | HDEF_1790 | HDEF_1784 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Essential cell division protein, stablilzes FtsZ ring, required for PBP2 expression; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.950 |
ftsL | mraW | HDEF_1790 | HDEF_1791 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | S-adenosyl-dependent methyl transferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.944 |
ftsL | mraZ | HDEF_1790 | HDEF_1792 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. | 0.860 |
ftsL | murC | HDEF_1790 | HDEF_1782 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme; Cell wall formation; Belongs to the MurCDEF family. | 0.870 |
ftsL | murD | HDEF_1790 | HDEF_1785 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.827 |
ftsL | murE | HDEF_1790 | HDEF_1788 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.858 |
ftsL | murF | HDEF_1790 | HDEF_1787 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | D-alanine:D-alanine-adding enzyme; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.835 |
ftsL | murG | HDEF_1790 | HDEF_1783 | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.822 |