STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (511 aa)    
Predicted Functional Partners:
Vdis_1757
COGs: COG0039 Malate/lactate dehydrogenase; InterPro IPR001557:IPR001236:IPR016040:IPR015955; KEGG: cma:Cmaq_1675 malate dehydrogenase; PFAM: Lactate/malate dehydrogenase; SPTR: A8MAC1 Malate dehydrogenase; PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; TIGRFAM: malate dehydrogenase, NAD-dependent; Belongs to the LDH/MDH superfamily.
     
 0.922
Vdis_0230
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.919
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.919
Vdis_0717
COGs: COG0469 Pyruvate kinase; InterProIPR015793:IPR015794:IPR015813:IPR015795:IPR 011037:IPR001697; KEGG: cma:Cmaq_0580 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: A8MCB5 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.908
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
Vdis_1845
2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterProIPR011278:IPR016142:IPR002020:IPR019810:IPR 016141; KEGG: cma:Cmaq_0306 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; SPTR: A8MB64 Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II.
     
 0.832
Vdis_0680
Chorismate mutase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086:IPR002912; KEGG: cma:Cmaq_1344 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Chorismate mutase; SPTR: A8M8V1 Prephenate dehydratase; PFAM: Prephenate dehydratase; ACT domain.
       0.551
Vdis_0682
COGs: COG0070 Glutamate synthase domain 3; InterPro IPR017932:IPR000583:IPR002489:IPR012075; KEGG: cma:Cmaq_0030 glutamate synthase alpha subunit; PFAM: glutamate synthase alpha subunit domain protein; glutamine amidotransferase class-II; SPTR: A8M9K3 Glutamate synthase alpha subunit domain protein; PFAM: GXGXG motif; Glutamine amidotransferases class-II.
 
     0.484
Vdis_1810
Protein of unknown function DUF211; COGs: COG1888 conserved hypothetical protein; InterPro IPR003831; KEGG: pis:Pisl_1129 hypothetical protein; PFAM: protein of unknown function DUF211; SPTR: A1RTL8 Putative uncharacterized protein; manually curated; PFAM: Uncharacterized ArCR, COG1888.
  
     0.409
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.