STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (607 aa)    
Predicted Functional Partners:
Vdis_1949
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR000097:IPR004808:IPR005135; KEGG: cma:Cmaq_1739 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: A8MAI5 Exodeoxyribonuclease III Xth; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
  
 
 0.986
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.955
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
 0.932
pcn-2
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.924
Vdis_2388
Helicase domain protein; COGs: COG1061 DNA or RNA helicase of superfamily II; InterProIPR006142:IPR006141:IPR014021:IPR001650:IPR 014001:IPR003587:IPR003586:IPR006935; KEGG: cma:Cmaq_0822 helicase domain-containing protein; PFAM: helicase domain protein; type III restriction protein res subunit; SMART: helicase domain protein; Hedgehog/intein hint domain protein; DEAD-like helicase; SPTR: A8MD01 Helicase domain protein; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; TIGRFAM: intein N-terminal splicing region; intein C-terminal splicing region.
  
 
 0.867
Vdis_2529
Putative mRNA 3-end processing factor; COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; InterPro IPR002355; KEGG: pas:Pars_1883 putative mRNA 3-end processing factor; SPTR: A4WM17 Putative mRNA 3-end processing factor.
 
 0.831
rfcL
AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
   
 0.827
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
  
 0.802
priS
DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
 
  
 0.801
Vdis_1836
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR017966:IPR006133:IPR006134:IPR017964:IPR 006172:IPR012337; KEGG: cma:Cmaq_0144 DNA polymerase I; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A8MA62 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
 
 0.791
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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