node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADG91834.1 | ADG91916.1 | Arnit_0167 | Arnit_0250 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.885 |
ADG91834.1 | ADG91917.1 | Arnit_0167 | Arnit_0251 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.889 |
ADG91834.1 | ADG91925.1 | Arnit_0167 | Arnit_0259 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.943 |
ADG91834.1 | ADG92366.1 | Arnit_0167 | Arnit_0701 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | COGs: COG0192 S-adenosylmethionine synthetase; InterPro IPR002133; KEGG: tdn:Suden_1476 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase; PRIAM: Methionine adenosyltransferase; SPTR: Q30QH8 Methionine adenosyltransferase; TIGRFAM: S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.417 |
ADG91834.1 | ADG93066.1 | Arnit_0167 | Arnit_1408 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | KEGG: cth:Cthe_2304 hypothetical protein; SPTR: A3DHS7 Putative uncharacterized protein; PFAM: Methylenetetrahydrofolate reductase. | 0.658 |
ADG91834.1 | ADG93116.1 | Arnit_0167 | Arnit_1459 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | COGs: COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); InterPro IPR003726; KEGG: bsu:BSU02410 homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: C2A2N3 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase. | 0.832 |
ADG91834.1 | ADG94732.1 | Arnit_0167 | Arnit_3085 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterProIPR006235:IPR000277:IPR015424:IPR015421:IPR 015422; KEGG: abu:Abu_2169 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; SPTR: A8EWR0 O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.900 |
ADG91834.1 | luxS | Arnit_0167 | Arnit_0267 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.822 |
ADG91834.1 | metE | Arnit_0167 | Arnit_0516 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.884 |
ADG91916.1 | ADG91834.1 | Arnit_0250 | Arnit_0167 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | 0.885 |
ADG91916.1 | ADG91917.1 | Arnit_0250 | Arnit_0251 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.984 |
ADG91916.1 | ADG91925.1 | Arnit_0250 | Arnit_0259 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |
ADG91916.1 | ADG93066.1 | Arnit_0250 | Arnit_1408 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | KEGG: cth:Cthe_2304 hypothetical protein; SPTR: A3DHS7 Putative uncharacterized protein; PFAM: Methylenetetrahydrofolate reductase. | 0.818 |
ADG91916.1 | ADG93116.1 | Arnit_0250 | Arnit_1459 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); InterPro IPR003726; KEGG: bsu:BSU02410 homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: C2A2N3 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase. | 0.925 |
ADG91916.1 | ADG94732.1 | Arnit_0250 | Arnit_3085 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterProIPR006235:IPR000277:IPR015424:IPR015421:IPR 015422; KEGG: abu:Abu_2169 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; SPTR: A8EWR0 O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.941 |
ADG91916.1 | luxS | Arnit_0250 | Arnit_0267 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.947 |
ADG91916.1 | metE | Arnit_0250 | Arnit_0516 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.968 |
ADG91917.1 | ADG91834.1 | Arnit_0251 | Arnit_0167 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | 0.889 |
ADG91917.1 | ADG91916.1 | Arnit_0251 | Arnit_0250 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.984 |
ADG91917.1 | ADG91925.1 | Arnit_0251 | Arnit_0259 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |