STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ADG91925.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1157 aa)    
Predicted Functional Partners:
ADG93066.1
KEGG: cth:Cthe_2304 hypothetical protein; SPTR: A3DHS7 Putative uncharacterized protein; PFAM: Methylenetetrahydrofolate reductase.
  
  
 0.989
metE
5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.985
ADG91916.1
COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
 
 0.980
ADG91917.1
Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
 
 0.980
ADG92366.1
COGs: COG0192 S-adenosylmethionine synthetase; InterPro IPR002133; KEGG: tdn:Suden_1476 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase; PRIAM: Methionine adenosyltransferase; SPTR: Q30QH8 Methionine adenosyltransferase; TIGRFAM: S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family.
 
 
 0.961
fhs
Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559:IPR020628; KEGG: mca:MCA2219 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Q605Q9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase.
  
 
 0.955
ADG94732.1
COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterProIPR006235:IPR000277:IPR015424:IPR015421:IPR 015422; KEGG: abu:Abu_2169 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; SPTR: A8EWR0 O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase.
  
 
 0.955
luxS
Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.953
ADG93116.1
COGs: COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); InterPro IPR003726; KEGG: bsu:BSU02410 homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: C2A2N3 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase.
  
 
0.950
ADG91834.1
COGs: COG0460 Homoserine dehydrogenase; InterProIPR016040:IPR019811:IPR016204:IPR005106:IPR 001342:IPR002912; KEGG: abu:Abu_0158 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: A8ER68 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain.
  
 
 0.943
Your Current Organism:
Arcobacter nitrofigilis
NCBI taxonomy Id: 572480
Other names: A. nitrofigilis DSM 7299, Arcobacter nitrofigilis DSM 7299, Arcobacter nitrofigilis str. DSM 7299, Arcobacter nitrofigilis strain DSM 7299
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