node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADB57343.1 | ADB57571.1 | Arcpr_0273 | Arcpr_0505 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | 0.910 |
ADB57343.1 | fen | Arcpr_0273 | Arcpr_1473 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | 0.984 |
ADB57343.1 | lig | Arcpr_0273 | Arcpr_0546 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.857 |
ADB57343.1 | mre11 | Arcpr_0273 | Arcpr_0059 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.676 |
ADB57343.1 | pcn | Arcpr_0273 | Arcpr_1253 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.998 |
ADB57343.1 | polB | Arcpr_0273 | Arcpr_0397 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.998 |
ADB57343.1 | rad50 | Arcpr_0273 | Arcpr_0060 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.776 |
ADB57343.1 | rfcL | Arcpr_0273 | Arcpr_0770 | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.919 |
ADB57571.1 | ADB57343.1 | Arcpr_0505 | Arcpr_0273 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | 0.910 |
ADB57571.1 | fen | Arcpr_0505 | Arcpr_1473 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | 0.927 |
ADB57571.1 | lig | Arcpr_0505 | Arcpr_0546 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.764 |
ADB57571.1 | mre11 | Arcpr_0505 | Arcpr_0059 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.724 |
ADB57571.1 | pcn | Arcpr_0505 | Arcpr_1253 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.980 |
ADB57571.1 | polB | Arcpr_0505 | Arcpr_0397 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.908 |
ADB57571.1 | rad50 | Arcpr_0505 | Arcpr_0060 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.571 |
ADB57571.1 | rfcL | Arcpr_0505 | Arcpr_0770 | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.738 |
fen | ADB57343.1 | Arcpr_1473 | Arcpr_0273 | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | KEGG: DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. | 0.984 |
fen | ADB57571.1 | Arcpr_1473 | Arcpr_0505 | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | PFAM: Replication factor C; SMART: Hedgehog/intein hint domain protein; AAA ATPase; KEGG: RFC4; replication factor C (activator 1) 4, 37kDa; K10755 replication factor C subunit 2/4. | 0.927 |
fen | lig | Arcpr_1473 | Arcpr_0546 | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.936 |
fen | mre11 | Arcpr_1473 | Arcpr_0059 | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.979 |