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sbcD protein (Klebsiella pneumoniae) - STRING interaction network
"sbcD" - Nuclease SbcCD subunit D in Klebsiella pneumoniae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
sbcDNuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3’->5’ double strand exonuclease that can open hairpins. It also has a 5’ single-strand endonuclease activity (401 aa)    
Predicted Functional Partners:
JG24_03945
With SbcD cleaves DNA hairpin structures; also has 5’ single-strand endonuclease activity; Derived by automated computational analysis using gene prediction method- Protein Homology (1045 aa)
 
  0.998
recD
Exonuclease V subunit alpha; Helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5’ to 3’ helicase activity; Derived by automated computational analysis using gene prediction method- Protein Homology (614 aa)
 
 
 
  0.796
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (352 aa)
   
 
  0.787
recB
Exodeoxyribonuclease V beta chain; Helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5’ to 3’ helicase activity; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the helicase family. UvrD subfamily (1178 aa)
         
  0.766
recC
Exodeoxyribonuclease V gamma chain; Catalyzes ATP-dependent exonucleolytic cleavage in either 5’- to 3’- or 3’- to 5’-direction to yield 5’-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; Derived by automated computational analysis using gene prediction method- Protein Homology (1125 aa)
   
   
  0.670
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (673 aa)
     
   
  0.640
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
   
 
  0.609
JG24_26575
ATP-dependent DNA helicase RecQ; Functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; Derived by automated computational analysis using gene prediction method- Protein Homology (608 aa)
   
 
  0.609
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (523 aa)
           
  0.605
JG24_27905
DNA mismatch repair protein MutL; Derived by automated computational analysis using gene prediction method- Protein Homology (619 aa)
     
 
  0.601
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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