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apt protein (Klebsiella pneumoniae) - STRING interaction network
"apt" - Adenine phosphoribosyltransferase in Klebsiella pneumoniae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (183 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; Derived by automated computational analysis using gene prediction method- Protein Homology (525 aa)
   
  0.991
JG24_08440
Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines- the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (456 aa)
   
  0.964
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP (207 aa)
   
 
  0.953
purH
Bifunctional purine biosynthesis protein PurH; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (529 aa)
   
 
  0.950
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family (214 aa)
   
 
  0.947
JG24_17105
Derived by automated computational analysis using gene prediction method- Protein Homology (603 aa)
       
  0.947
gpt
Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily (152 aa)
   
  0.930
JG24_04565
Inosine-guanosine kinase; Catalyzes the formation of inosine/guanosine monophosphate from inosine or guanosine and ATP; Derived by automated computational analysis using gene prediction method- Protein Homology (434 aa)
   
  0.929
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (347 aa)
   
 
  0.927
deoD
Purine-nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2’- deoxyribonucleosides to the free base and (2’-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
       
  0.926
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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