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holA protein (Klebsiella pneumoniae) - STRING interaction network
"holA" - DNA polymerase III subunit delta in Klebsiella pneumoniae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
holADNA polymerase III subunit delta; Required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; Derived by automated computational analysis using gene prediction method- Protein Homology (343 aa)    
Predicted Functional Partners:
JG24_04535
DNA polymerase III subunits gamma and tau; Catalyzes the DNA-template-directed extension of the 3’-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta’ subunits to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method- Protein Homology (635 aa)
 
  0.996
JG24_08210
DNA polymerase III delta prime subunit; Catalyzes the DNA-template-directed extension of the 3’-end of a DNA strand; the delta’ subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method- Protein Homology (334 aa)
 
  0.994
JG24_25485
DNA polymerase III beta subunit; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method- Protein Homology (366 aa)
 
  0.992
JG24_29270
With the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method- Protein Homology (137 aa)
   
  0.989
lptE
LPS-assembly lipoprotein LptE; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane (196 aa)
   
  0.980
JG24_05775
Derived by automated computational analysis using gene prediction method- Protein Homology (216 aa)
 
   
  0.970
leuS
Leucyl-tRNA synthetase; leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; Derived by [...] (860 aa)
 
        0.959
JG24_28400
DNA polymerase III chi subunit; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method- Protein Homology (147 aa)
   
  0.951
dnaE
DNA-directed DNA polymerase; Catalyzes DNA-template-directed extension of the 3’- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method- Protein Homology (1160 aa)
     
  0.947
dnaQ
DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3’-5’ exonuclease (243 aa)
   
 
  0.909
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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