STRINGSTRING
nei protein (Klebsiella pneumoniae) - STRING interaction network
"nei" - Endonuclease 8 in Klebsiella pneumoniae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
neiEndonuclease 8; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3’- and 5’- phosphates (263 aa)    
Predicted Functional Partners:
JG24_06065
Derived by automated computational analysis using gene prediction method- Protein Homology (250 aa)
       
  0.945
JG24_06060
Derived by automated computational analysis using gene prediction method- Protein Homology (310 aa)
   
 
  0.934
JG24_06050
Derived by automated computational analysis using gene prediction method- Protein Homology (247 aa)
       
  0.925
JG24_06055
Derived by automated computational analysis using gene prediction method- Protein Homology (218 aa)
       
  0.921
JG24_06070
Derived by automated computational analysis using gene prediction method- Protein Homology (214 aa)
              0.842
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
   
   
  0.789
JG24_06040
Deoxyribodipyrimidine photolyase; UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the DNA photolyase family (480 aa)
 
   
  0.750
sdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) (115 aa)
 
       
  0.745
sdhC
Succinate dehydrogenase cytochrome b-556 subunit; Derived by automated computational analysis using gene prediction method- Protein Homology (134 aa)
 
       
  0.720
JG24_15885
Protease II; PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; Derived by automated computational analysis using gene prediction method- Protein Homology (686 aa)
           
  0.651
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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