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JG24_07000 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_07000" - Low-specificity L-threonine aldolase in Klebsiella pneumoniae
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
JG24_07000Low-specificity L-threonine aldolase; Low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; Derived by automated computational analysis using gene prediction method- Protein Homology (333 aa)    
Predicted Functional Partners:
JG24_21255
Glycine dehydrogenase [decarboxylating] (Glycine cleavage system P protein); Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; Derived by automated computational analysis using gene prediction method- Protein Homology (957 aa)
 
 
  0.970
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
     
  0.953
JG24_15450
Threonine dehydratase, catabolic; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method- Protein Homology (329 aa)
   
 
  0.932
ilvA
L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (514 aa)
   
 
  0.927
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA (397 aa)
     
  0.922
tdh
L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family (341 aa)
 
     
  0.922
JG24_29430
Threonine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology (426 aa)
     
  0.917
JG24_11420
NADP(+)-dependent; catalyzes the formation of 3-hydroxypropionate from the toxic malonic semialdehyde, catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family (249 aa)
       
    0.904
JG24_06995
Uncharacterized protein; Derived by automated computational analysis using gene prediction method- Protein Homology (480 aa)
   
        0.895
JG24_12470
Serine--pyruvate aminotransferase / L-alanine-glyoxylate aminotransferase; Derived by automated computational analysis using gene prediction method- Protein Homology (413 aa)
   
 
  0.856
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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