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lapB protein (Klebsiella pneumoniae) - STRING interaction network
"lapB" - Lipopolysaccharide assembly protein B in Klebsiella pneumoniae
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second shell of interactors
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lapBLipopolysaccharide assembly protein B; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane (389 aa)    
Predicted Functional Partners:
lapA
Lipopolysaccharide assembly protein A; Involved in the assembly of lipopolysaccharide (LPS) (102 aa)
 
   
  0.952
hisS
Histidine--tRNA ligase; Catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; Derived by automated computational analysis using gene prediction method- Protein Homology (424 aa)
           
  0.651
JG24_09605
Derived by automated computational analysis using gene prediction method- Protein Homology (255 aa)
 
          0.615
pyrF
Orotidine 5’-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5’- monophosphate (OMP) to uridine 5’-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily (245 aa)
              0.614
lpxH
UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (240 aa)
   
 
      0.595
ftsB
Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (105 aa)
   
          0.593
bamE
Outer membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (113 aa)
   
          0.562
JG24_09625
Translation initiation factor SUI1-related protein; Involved in start site selection during the initiation of translation; Derived by automated computational analysis using gene prediction method- Protein Homology (108 aa)
              0.558
JG24_23180
Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (162 aa)
   
          0.557
sspA
Stringent starvation protein A; Transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the GST superfamily (212 aa)
   
          0.557
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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