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nth protein (Klebsiella pneumoniae) - STRING interaction network
"nth" - Endonuclease III in Klebsiella pneumoniae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (211 aa)    
Predicted Functional Partners:
JG24_13575
Electron transport complex subunit E; Part of a membrane complex involved in electron transport (232 aa)
 
   
  0.977
rnfD
Electron transport complex subunit D; Part of a membrane complex involved in electron transport (350 aa)
   
   
  0.939
JG24_13555
Electron transport complex protein RnfB; Part of a membrane complex involved in electron transport (192 aa)
   
   
  0.916
JG24_13570
Electron transport complex subunit G; Part of a membrane complex involved in electron transport (206 aa)
   
   
  0.902
JG24_13550
Electron transport complex subunit A; Part of a membrane complex involved in electron transport (193 aa)
       
  0.884
JG24_13560
Derived by automated computational analysis using gene prediction method- Protein Homology (753 aa)
   
   
  0.881
JG24_09300
Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method- Protein Homology (268 aa)
 
 
 
  0.873
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
   
 
  0.731
nqrD
Na(+)-translocating NADH-quinone reductase subunit D; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family (212 aa)
 
       
  0.701
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (229 aa)
 
 
  0.684
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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