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hemA protein (Klebsiella pneumoniae) - STRING interaction network
"hemA" - Glutamyl-tRNA reductase in Klebsiella pneumoniae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA); Belongs to the glutamyl-tRNA reductase family (418 aa)    
Predicted Functional Partners:
JG24_30310
Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method- Protein Homology (426 aa)
 
  0.995
hemC
Transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (313 aa)
   
  0.990
gltX
Glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (472 aa)
     
 
  0.953
JG24_03835
Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the ALAD family (324 aa)
 
   
  0.924
prfA
Peptide chain release factor 1; Recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; Derived by automated computational analysis using gene prediction method- Protein Homology (360 aa)
   
   
  0.888
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (354 aa)
 
   
  0.885
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme (457 aa)
 
  0.850
JG24_20125
Derived by automated computational analysis using gene prediction method- Protein Homology (471 aa)
 
  0.847
JG24_15140
HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; Derived by automated computational analysis using gene prediction method- Protein Homology (282 aa)
   
        0.828
JG24_15130
FIG002708- Protein SirB1; Derived by automated computational analysis using gene prediction method- Protein Homology (270 aa)
              0.781
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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