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sirA protein (Klebsiella pneumoniae) - STRING interaction network
"sirA" - BarA-associated response regulator UvrY (= GacA = SirA) in Klebsiella pneumoniae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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sirABarA-associated response regulator UvrY (= GacA = SirA); In Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; Derived by automated computational analysis using gene prediction method- Protein Homology (218 aa)    
Predicted Functional Partners:
JG24_20205
Histidine kinase; Part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; Derived by automated computational analysis using gene prediction method- Protein Homology (916 aa)
 
  0.979
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5’ and 3’ sides of the lesion. The N-terminal half is responsible for the 3’ incision and the C-terminal half is responsible for the 5’ incision (610 aa)
 
   
  0.956
JG24_16190
Derived by automated computational analysis using gene prediction method- Protein Homology (240 aa)
 
 
  0.910
JG24_16170
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family (182 aa)
         
  0.788
JG24_09885
Derived by automated computational analysis using gene prediction method- Protein Homology (897 aa)
 
 
  0.781
JG24_22980
Aerobic respiration control sensor protein arcB; Sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; Derived by automated computational analysis using gene prediction method- Protein Homology (779 aa)
 
 
  0.778
envZ
Membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method- Protein Homology (451 aa)
   
 
 
  0.684
JG24_22255
Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Derived by automated computational analysis using gene prediction method- Protein Homology (1080 aa)
   
 
  0.680
csrA
Carbon storage regulator homolog; Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (61 aa)
           
  0.646
ompR
Part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
   
 
  0.645
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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