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hisD protein (Klebsiella pneumoniae) - STRING interaction network
"hisD" - Catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis in Klebsiella pneumoniae
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experimentally determined
Predicted Interactions
gene neighborhood
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textmining
co-expression
protein homology
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Score
hisDCatalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; Derived by automated computational analysis using gene prediction method- Protein Homology (434 aa)    
Predicted Functional Partners:
hisB
Histidine biosynthesis bifunctional protein HisB; Catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; Derived by automated computational analysis using gene prediction method- Protein Homology; In the N-terminal section; belongs to the histidinol- phosphatase family (355 aa)
 
  0.999
hisI
Histidine biosynthesis bifunctional protein HisIE; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology; In the N-terminal section; belongs to the PRA-CH family (199 aa)
   
  0.999
JG24_16755
Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (353 aa)
 
  0.999
hisH
Imidazole glycerol phosphate synthase; With HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; Derived by automated computational analysis using gene prediction method- Protein H [...] (196 aa)
   
  0.998
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (258 aa)
 
  0.998
hisG
ATP phosphoribosyltransferase; Long form of enzyme; catalyzes the formation of N’-5’-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; Derived by automated computational analysis using gene prediction method- Protein Homology (299 aa)
 
 
  0.997
JG24_16770
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the HisA/HisF family (245 aa)
   
  0.996
JG24_06415
Catalyzes the degradation of histidine to urocanate and ammmonia; Derived by automated computational analysis using gene prediction method- Protein Homology (508 aa)
       
    0.902
purE
N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the formation of 4-carboxy-5-aminoimidazole ribonucleotide from N5-carboxyaminoimidazole ribonucleotide; Derived by automated computational analysis using gene prediction method- Protein Homology (169 aa)
 
     
  0.869
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5’-phosphoribosyl)-anthranilate (PRA) (531 aa)
 
   
  0.860
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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