STRINGSTRING
nfo protein (Klebsiella pneumoniae) - STRING interaction network
"nfo" - Probable endonuclease 4 in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoProbable endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (284 aa)    
Predicted Functional Partners:
JG24_17335
Putative membrane protein YeiH; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the UPF0324 family (349 aa)
              0.685
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
   
 
  0.666
JG24_26060
Manganese superoxide dismutase; SodA; manganese binding; only present under aerobic conditions; destroys free radicals; Derived by automated computational analysis using gene prediction method- Protein Homology (206 aa)
   
   
  0.593
JG24_09300
Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method- Protein Homology (268 aa)
     
 
  0.585
JG24_21480
A/G-specific adenine glycosylase; Derived by automated computational analysis using gene prediction method- Protein Homology (352 aa)
     
   
  0.569
rplW
50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (100 aa)
         
  0.497
rpmC
50S ribosomal protein L29; One of the stabilizing components for the large ribosomal subunit; Derived by automated computational analysis using gene prediction method- Protein Homology (63 aa)
         
  0.491
argR
Arginine repressor; Regulates arginine biosynthesis genes (156 aa)
           
  0.486
JG24_17330
Derived by automated computational analysis using gene prediction method- Protein Homology (66 aa)
              0.476
greA
Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3’terminus. GreA releases sequences of 2 to 3 nucleotides (158 aa)
           
  0.475
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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