STRINGSTRING
upp protein (Klebsiella pneumoniae) - STRING interaction network
"upp" - Uracil phosphoribosyltransferase in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (208 aa)    
Predicted Functional Partners:
udk
Uridine kinase; Derived by automated computational analysis using gene prediction method- Protein Homology (213 aa)
 
  0.992
pyrF
Orotidine 5’-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5’- monophosphate (OMP) to uridine 5’-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily (245 aa)
   
 
  0.974
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP (241 aa)
   
 
  0.965
deoA
Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family (440 aa)
 
 
  0.956
JG24_26625
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family (253 aa)
   
 
  0.946
JG24_23660
Cytosine deaminase; Catalyzes the deamination of cytosine to uracil and ammonia; Derived by automated computational analysis using gene prediction method- Protein Homology (440 aa)
   
 
  0.937
JG24_05570
Catalyzes the deamination of cytosine to uracil and ammonia; Derived by automated computational analysis using gene prediction method- Protein Homology (412 aa)
   
 
  0.937
JG24_18630
Uracil permease; Derived by automated computational analysis using gene prediction method- Protein Homology (428 aa)
   
  0.929
JG24_13980
Derived by automated computational analysis using gene prediction method- Protein Homology (427 aa)
   
 
  0.928
deoD
Purine-nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2’- deoxyribonucleosides to the free base and (2’-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
       
  0.927
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
Server load: low (5%) [HD]