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JG24_18830 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_18830" - Iron-sulfur cluster assembly scaffold protein IscU in Klebsiella pneumoniae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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JG24_18830Iron-sulfur cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (128 aa)    
Predicted Functional Partners:
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily (404 aa)
 
 
  0.994
hscB
Co-chaperone protein HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (171 aa)
 
 
  0.990
hscA
Chaperone protein HscA; Involved in the maturation of iron-sulfur cluster-containing proteins; Derived by automated computational analysis using gene prediction method- Protein Homology (616 aa)
 
 
  0.967
JG24_18810
Ferredoxin, 2Fe-2S; Derived by automated computational analysis using gene prediction method- Protein Homology (111 aa)
 
 
  0.965
JG24_16680
Derived by automated computational analysis using gene prediction method- Protein Homology (400 aa)
 
 
  0.965
iscA
Iron-binding protein IscA; Forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; Derived by automated computational analysis using gene prediction method- Protein Homology (107 aa)
   
  0.951
JG24_18840
Iron-sulfur cluster regulator IscR; Regulates the expression of the iscRSUA operon; Derived by automated computational analysis using gene prediction method- Protein Homology (163 aa)
   
   
  0.896
JG24_18805
Believed to be involved in assembly of Fe-S clusters; Derived by automated computational analysis using gene prediction method- Protein Homology (66 aa)
 
   
  0.876
cyaY
Protein CyaY; Iron-dependent inhibitor of iron-sulfur cluster formation; iron-binding and oxidizing protein; defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; Derived by automated computational analysis using gene prediction method- Protein Homology (106 aa)
   
 
  0.841
nfuA
Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins (191 aa)
   
 
  0.786
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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