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JG24_18895 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_18895" - Nitrogen regulatory protein P-II in Klebsiella pneumoniae
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Predicted Interactions
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textmining
co-expression
protein homology
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JG24_18895Nitrogen regulatory protein P-II; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method- Protein Homology (112 aa)    
Predicted Functional Partners:
JG24_04335
Ammonium transporter; Derived by automated computational analysis using gene prediction method- Protein Homology (428 aa)
 
  0.990
glnD
Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism (887 aa)
 
  0.958
glnL
Nitrogen regulation protein NtrB; Sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; Derived by automated computational analysis using gene prediction method- Protein Homology (349 aa)
   
  0.927
gltB
Glutamate synthase [NADPH] large chain; Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method- Protein Homology (1486 aa)
 
   
  0.847
JG24_18900
Putative sensory histidine kinase YfhA; With GlrK is part of a two-component signal transduction system regulating glmY; Derived by automated computational analysis using gene prediction method- Protein Homology (445 aa)
         
  0.676
JG24_18905
Putative alpha helix protein; Derived by automated computational analysis using gene prediction method- Protein Homology (228 aa)
         
  0.670
JG24_21745
Catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; Derived by automated computational analysis using gene prediction method- Protein Homology (945 aa)
 
 
  0.644
glnA
Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method- Protein Homology (469 aa)
 
 
  0.637
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate (257 aa)
   
 
  0.612
JG24_18910
Putative sensor-like histidine kinase YfhK; Part of the GlrKR two-component signal transduction system involved in the regulation of glmY; Derived by automated computational analysis using gene prediction method- Protein Homology (479 aa)
         
  0.604
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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