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JG24_18995 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_18995" - Anti-sigma-E factor RseA in Klebsiella pneumoniae
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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JG24_18995Anti-sigma-E factor RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish de [...] (216 aa)    
Predicted Functional Partners:
rseB
Sigma factor RpoE negative regulatory protein RseB; Periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; Derived by automated computational analysis using gene prediction method- Protein Homology (318 aa)
 
  0.999
JG24_19000
RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily (191 aa)
 
 
  0.999
JG24_18985
Involved in the reduction of the SoxR iron-sulfur cluster; Derived by automated computational analysis using gene prediction method- Protein Homology (159 aa)
 
   
  0.957
JG24_30410
Zinc metalloprotease; Catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; Derived by automated computational analysis using gene prediction method- Protein Homology (450 aa)
   
 
  0.810
JG24_02595
Derived by automated computational analysis using gene prediction method- Protein Homology (181 aa)
   
 
  0.731
JG24_00660
Derived by automated computational analysis using gene prediction method- Protein Homology (181 aa)
   
 
  0.731
JG24_18580
Derived by automated computational analysis using gene prediction method- Protein Homology (344 aa)
   
          0.707
rraB
Regulator of ribonuclease activity B; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (140 aa)
   
          0.697
JG24_19010
tRNA1(Val) (adenine(37)-N6)-methyltransferase; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (245 aa)
 
            0.697
JG24_26115
Cell division protein FtsN; Derived by automated computational analysis using gene prediction method- Protein Homology (282 aa)
   
          0.678
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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