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JG24_19625 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_19625" - S-ribosylhomocysteine lyase in Klebsiella pneumoniae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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JG24_19625S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD); Belongs to the LuxS family (171 aa)    
Predicted Functional Partners:
JG24_30335
5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5’-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5’-methylthioribose and S-ribosylhomocysteine, respectively; Belongs to the PNP/UDP phosphorylase family. MtnN subfamily (232 aa)
 
   
  0.989
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; One of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; Derived by automated computational analysis using gene prediction method- Protein Homology (1227 aa)
       
  0.976
JG24_21520
Cystathionine gamma-lyase; Derived by automated computational analysis using gene prediction method- Protein Homology (382 aa)
       
  0.933
JG24_21515
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method- Protein Homology (456 aa)
       
  0.927
metE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (754 aa)
       
  0.924
JG24_14715
Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method- Protein Homology (343 aa)
       
  0.924
JG24_26145
Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method- Protein Homology (386 aa)
       
  0.920
JG24_11600
Methionine synthase II (Cobalamin-independent); Derived by automated computational analysis using gene prediction method- Protein Homology (367 aa)
       
  0.919
JG24_21595
Cystathionine beta-lyase; Catalyzes the formation of L-homocysteine from cystathionine; Derived by automated computational analysis using gene prediction method- Protein Homology (395 aa)
       
  0.918
JG24_10635
Cystathionine beta-lyase (CBL) (Beta-cystathionase) (Cysteine lyase) / Maltose regulon modulator; Catalyzes the formation of homocysteine and pyruvate from cystathionine; also acts a a negative regulator for the mal regulon but interacting with the transcriptional activator MalT; Derived by automated computational analysis using gene prediction method- Protein Homology (390 aa)
         
  0.909
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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