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nudH protein (Klebsiella pneumoniae) - STRING interaction network
"nudH" - RNA pyrophosphohydrolase in Klebsiella pneumoniae
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
nudHRNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5’-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (176 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (264 aa)
 
      0.912
JG24_20705
FIG001592- Phosphocarrier protein kinase/phosphorylase, nitrogen regulation associated; Member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; Derived by automated computational analysis using gene prediction method- Protein Homology (748 aa)
   
   
  0.905
lgt
Prolipoprotein diacylglyceryl transferase; Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (291 aa)
 
        0.864
dapF
Involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; Derived by automated computational analysis using gene prediction method- Protein Homology (274 aa)
   
 
  0.862
rapZ
RNase adapter protein RapZ; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS (284 aa)
         
  0.658
frsA
Uncharacterized protein; Forms a 1-1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; Derived by automated computational analysis using gene prediction method- Protein Homology (414 aa)
         
  0.651
tolB
Protein TolB; Involved in the TonB-independent uptake of proteins (430 aa)
 
          0.578
pcnB
Polymerase that creates the 3’ poly(A) tail found in some mRNA’s; Derived by automated computational analysis using gene prediction method- Protein Homology (453 aa)
 
   
  0.563
JG24_23800
Derived by automated computational analysis using gene prediction method- Protein Homology (776 aa)
     
 
  0.561
orn
Oligoribonuclease; 3’-to-5’ exoribonuclease specific for small oligoribonucleotides (181 aa)
   
   
  0.554
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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