STRINGSTRING
lysA protein (Klebsiella pneumoniae) - STRING interaction network
"lysA" - Diaminopimelate decarboxylase in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (420 aa)    
Predicted Functional Partners:
JG24_27070
Aspartokinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; Derived by automated computational analysis using gene prediction method- Protein Homology (449 aa)
 
  0.977
dapF
Involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; Derived by automated computational analysis using gene prediction method- Protein Homology (274 aa)
 
 
  0.975
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; Derived by automated computational analysis using gene prediction method- Protein Homology (495 aa)
     
 
  0.943
JG24_18585
Dihydrodipicolinate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the DapA family (292 aa)
   
  0.915
thrA
Aspartokinase / Homoserine dehydrogenase; Multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; Derived by automated computational analysis using gene prediction method- Protein Homology (820 aa)
 
  0.878
dapB
4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (273 aa)
 
   
  0.875
metL
Homoserine dehydrogenase; Multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; Derived by automated computational analysis using gene prediction method- Protein Homology (810 aa)
 
  0.865
JG24_04830
Lysine decarboxylase, inducible; Constitutive; catalyzes the formation of cadaverine from lysine; Derived by automated computational analysis using gene prediction method- Protein Homology (715 aa)
       
  0.830
JG24_03100
Constitutive; catalyzes the formation of cadaverine from lysine; Derived by automated computational analysis using gene prediction method- Protein Homology (717 aa)
       
  0.830
dapD
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the transferase hexapeptide repeat family (274 aa)
 
   
  0.818
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
Server load: low (5%) [HD]