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JG24_21680 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_21680" - 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA in Klebsiella pneumoniae
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
JG24_216803’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (275 aa)    
Predicted Functional Partners:
cyaA
Adenylate cyclase; Catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3’-hydroxyl group to form cyclic AMP; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the adenylyl cyclase class-1 family (850 aa)
   
   
  0.987
JG24_21675
Putative esterase, FIGfam005057; Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; Derived by automated computational analysis using gene prediction method- Protein Homology (191 aa)
 
        0.970
nudF
ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; Derived by automated computational analysis using gene prediction method- Protein Homology (210 aa)
        0.923
mazG
Nucleoside triphosphate pyrophosphohydrolase MazG; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method- Protein Homology (263 aa)
   
 
    0.918
JG24_23760
FIG001957- putative hydrolase; Derived by automated computational analysis using gene prediction method- Protein Homology (227 aa)
   
   
    0.912
ushA
UDP-sugar hydrolase 5’-nucleotidase; Catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the 5’-nucleotidase family (550 aa)
       
  0.912
surE
5’/3’-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5’- monophosphates and ribonucleoside 3’-monophosphates with highest affinity to 3’-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3’-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs (253 aa)
     
 
    0.904
JG24_08440
Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines- the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (456 aa)
   
 
    0.903
JG24_20255
Decarboxylase family protein; Derived by automated computational analysis using gene prediction method- Protein Homology (455 aa)
     
 
    0.901
JG24_13755
Cytokinin riboside 5’-monophosphate phosphoribohydrolase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the LOG family (192 aa)
     
 
    0.901
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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