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ureC protein (Klebsiella pneumoniae) - STRING interaction network
"ureC" - Urease subunit alpha in Klebsiella pneumoniae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
ureCUrease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method- Protein Homology (567 aa)    
Predicted Functional Partners:
ureB
Urease subunit beta; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem [...] (106 aa)
  0.999
ureA
Urease subunit gamma; UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; Derived by automated computational analysis using gene prediction method- Protein Homology (100 aa)
  0.999
JG24_21815
Derived by automated computational analysis using gene prediction method- Protein Homology (224 aa)
 
 
  0.998
JG24_21810
Involved in the assembly of the urease metallocenter; possible nickel donor; Derived by automated computational analysis using gene prediction method- Protein Homology (158 aa)
 
   
  0.997
JG24_21820
Derived by automated computational analysis using gene prediction method- Protein Homology (205 aa)
 
   
  0.988
JG24_21790
Derived by automated computational analysis using gene prediction method- Protein Homology (274 aa)
 
   
  0.986
JG24_21825
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN; Derived by automated computational analysis using gene prediction method- Protein Homology (535 aa)
   
  0.886
gltB
Glutamate synthase [NADPH] large chain; Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method- Protein Homology (1486 aa)
           
  0.693
JG24_12375
Derived by automated computational analysis using gene prediction method- Protein Homology (1201 aa)
         
  0.618
JG24_21785
Derived by automated computational analysis using gene prediction method- Protein Homology (48 aa)
              0.618
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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