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mscL protein (Klebsiella pneumoniae) - STRING interaction network
"mscL" - Large-conductance mechanosensitive channel in Klebsiella pneumoniae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (137 aa)    
Predicted Functional Partners:
trkA
Trk system potassium uptake protein TrkA; Involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; Derived by automated computational analysis using gene prediction method- Protein Homology (458 aa)
       
  0.909
kefB
Glutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport (601 aa)
         
  0.760
JG24_06015
Sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; Derived by automated computational analysis using gene prediction method- Protein Homology (895 aa)
           
  0.682
JG24_07045
Macrolide export ATP-binding/permease protein MacB; With MacA is involved in the export of macrolide; Derived by automated computational analysis using gene prediction method- Protein Homology (646 aa)
 
     
  0.631
JG24_23345
Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA (431 aa)
              0.623
treA
Trehalase; Periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; Derived by automated computational analysis using gene prediction method- Protein Homology (577 aa)
           
  0.586
JG24_21335
Protein involved in stability of MscS mechanosensitive channel; Participates in the regulation of osmotic pressure changes within the cel; Derived by automated computational analysis using gene prediction method- Protein Homology (285 aa)
         
  0.558
envZ
Membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method- Protein Homology (451 aa)
           
  0.554
JG24_29620
Glutathione-regulated potassium-efflux system protein KefC; Transport system that facilitates potassium-efflux; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family (621 aa)
         
  0.515
JG24_06870
TrkA, Potassium channel-family protein; Derived by automated computational analysis using gene prediction method- Protein Homology (561 aa)
         
  0.510
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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