STRINGSTRING
aroB protein (Klebsiella pneumoniae) - STRING interaction network
"aroB" - 3-dehydroquinate synthase in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) (364 aa)    
Predicted Functional Partners:
aroK
Shikimate kinase 1; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family (173 aa)
   
  0.998
aroD
3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate; Belongs to the type-I 3-dehydroquinase family (251 aa)
     
  0.990
JG24_03915
Shikimate kinase 1; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family (177 aa)
   
  0.979
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate; Belongs to the type-II 3-dehydroquinase family (150 aa)
 
  0.971
JG24_19130
Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (356 aa)
   
 
  0.967
JG24_06240
Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (350 aa)
   
 
  0.967
JG24_07175
3-phosphoshikimate 1-carboxyvinyltransferase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the EPSP synthase family (427 aa)
   
  0.957
aroE
Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) (272 aa)
   
  0.936
JG24_14765
2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha; Derived by automated computational analysis using gene prediction method- Protein Homology (348 aa)
 
 
  0.933
JG24_18090
Catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (361 aa)
 
   
  0.912
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
Server load: low (8%) [HD]