STRINGSTRING
envZ protein (Klebsiella pneumoniae) - STRING interaction network
"envZ" - Membrane-localized osmosensor in Klebsiella pneumoniae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
envZMembrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method- Protein Homology (451 aa)    
Predicted Functional Partners:
ompR
Part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
  0.999
JG24_26075
Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method- Protein Homology (232 aa)
 
 
  0.836
JG24_12750
Putative two-component response regulator transcriptional regulatory protein; Derived by automated computational analysis using gene prediction method- Protein Homology (246 aa)
 
  0.808
JG24_10690
Transcriptional regulatory protein RstA; Response regulator in two-component regulatory system with RstB; Derived by automated computational analysis using gene prediction method- Protein Homology (240 aa)
 
 
  0.756
JG24_08425
Transcriptional regulatory protein PhoP; Response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; Derived by automated computational analysis using gene prediction method- Protein Homology (223 aa)
 
 
 
  0.751
rssB
Regulator of RpoS; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation (337 aa)
   
 
  0.736
JG24_03955
Phosphate regulon transcriptional regulatory protein PhoB (SphR); Two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; Derived by automated computational analysis using gene prediction method- Protein Homology (229 aa)
 
 
 
  0.730
JG24_18070
Uncharacterized protein; Derived by automated computational analysis using gene prediction method- Protein Homology (93 aa)
   
          0.691
sirA
BarA-associated response regulator UvrY (= GacA = SirA); In Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; Derived by automated computational analysis using gene prediction method- Protein Homology (218 aa)
   
 
 
  0.684
mzrA
Modulator protein MzrA; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (127 aa)
   
 
 
  0.640
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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