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cpxA protein (Klebsiella pneumoniae) - STRING interaction network
"cpxA" - Copper sensory histidine kinase CpxA in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
cpxACopper sensory histidine kinase CpxA; Part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; Derived by automated computational analysis using gene prediction method- Protein Homology (457 aa)    
Predicted Functional Partners:
JG24_26075
Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method- Protein Homology (232 aa)
  0.999
cpxP
P pilus assembly/Cpx signaling pathway,periplasmic inhibitor/zinc-resistance associated protein; Repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; Derived by automated computational analysis using gene prediction method- Protein Homology (167 aa)
 
     
  0.920
JG24_03135
Copper homeostasis protein CutF / Lipoprotein NlpE involeved in surface adhesion; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
     
 
  0.846
ompR
Part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
 
  0.837
JG24_17005
Response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; Derived by automated computational analysis using gene prediction method- Protein Homology (240 aa)
 
 
  0.764
rssB
Regulator of RpoS; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation (337 aa)
   
 
  0.732
JG24_18580
Derived by automated computational analysis using gene prediction method- Protein Homology (344 aa)
   
        0.673
JG24_08425
Transcriptional regulatory protein PhoP; Response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; Derived by automated computational analysis using gene prediction method- Protein Homology (223 aa)
 
 
 
  0.667
JG24_30090
Predicted chaperone lipoprotein YacC, potentially involved in protein secretion; Derived by automated computational analysis using gene prediction method- Protein Homology (115 aa)
   
          0.665
JG24_09335
Periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; Derived by automated computational analysis using gene prediction method- Protein Homology (160 aa)
 
     
  0.628
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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