STRINGSTRING
fieF protein (Klebsiella pneumoniae) - STRING interaction network
"fieF" - Cobalt-zinc-cadmium resistance protein in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fieFCobalt-zinc-cadmium resistance protein; Member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family (300 aa)    
Predicted Functional Partners:
zntA
P-type ATPase involved in the export of lead, cadmium, zinc and mercury; Derived by automated computational analysis using gene prediction method- Protein Homology (736 aa)
   
   
  0.704
feoB
Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system (772 aa)
         
  0.662
mntP
Putative manganese efflux pump MntP; Probably functions as a manganese efflux pump (188 aa)
         
  0.553
zraP
Zinc resistance-associated protein; Derived by automated computational analysis using gene prediction method- Protein Homology (145 aa)
         
  0.539
JG24_17900
Catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; Derived by automated computational analysis using gene prediction method- Protein Homology (715 aa)
         
  0.532
JG24_21375
Arginine decarboxylase; Catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (658 aa)
           
  0.527
cpxP
P pilus assembly/Cpx signaling pathway,periplasmic inhibitor/zinc-resistance associated protein; Repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; Derived by automated computational analysis using gene prediction method- Protein Homology (167 aa)
         
  0.526
pfkA
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (320 aa)
   
        0.507
JG24_21740
Bifunctional protein HldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose; In the N-terminal section; belongs to the carbohydrate kinase PfkB family (477 aa)
 
   
  0.473
znuC
Zinc ABC transporter, ATP-binding protein ZnuC; Involved in transport of zinc(II) with ZnuA and C; Derived by automated computational analysis using gene prediction method- Protein Homology (250 aa)
 
     
  0.407
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
Server load: low (4%) [HD]