STRINGSTRING
trmA protein (Klebsiella pneumoniae) - STRING interaction network
"trmA" - tRNA/tmRNA in Klebsiella pneumoniae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trmAtRNA/tmRNA (uracil-C(5))-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) (366 aa)    
Predicted Functional Partners:
truD
tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (349 aa)
   
 
  0.665
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family (239 aa)
   
   
  0.653
yebU
Ribosomal RNA small subunit methyltransferase F ## SSU rRNA m5C1407; In Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; Derived by automated computational analysis using gene prediction method- Protein Homology (477 aa)
     
 
  0.583
JG24_23345
Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA (431 aa)
   
 
  0.581
JG24_18565
Cetylates the wobble base C34 of the elongation-specific methionine tRNA; Derived by automated computational analysis using gene prediction method- Protein Homology (667 aa)
     
        0.574
JG24_17450
Catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the pseudouridine synthase RsuA family (239 aa)
 
   
  0.569
JG24_19625
S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD); Belongs to the LuxS family (171 aa)
   
          0.551
dusC
tRNA-dihydrouridine(16) synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs; Belongs to the dus family (310 aa)
 
   
  0.540
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis (283 aa)
   
        0.507
JG24_16025
tRNA (Uridine-5-oxyacetic acid methyl ester) 34 synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) (247 aa)
 
 
  0.499
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
Server load: low (4%) [HD]