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ilvE protein (Klebsiella pneumoniae) - STRING interaction network
"ilvE" - Branched-chain-amino-acid aminotransferase in Klebsiella pneumoniae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ilvEBranched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (309 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the IlvD/Edd family (616 aa)
   
  0.995
ilvA
L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (514 aa)
   
 
  0.984
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (523 aa)
 
  0.948
JG24_19615
Derived by automated computational analysis using gene prediction method- Protein Homology (558 aa)
   
  0.936
ilvM
Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method- Protein Homology (85 aa)
   
   
  0.931
JG24_26145
Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method- Protein Homology (386 aa)
 
  0.928
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; Derived by automated computational analysis using gene prediction method- Protein Homology (263 aa)
       
  0.921
JG24_21520
Cystathionine gamma-lyase; Derived by automated computational analysis using gene prediction method- Protein Homology (382 aa)
   
  0.917
avtA
Valine--pyruvate aminotransferase; Transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (418 aa)
     
 
  0.903
gshA
Glutamate--cysteine ligase; Involved in the first step of glutathione biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily (518 aa)
         
    0.900
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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