STRINGSTRING
cyaY protein (Klebsiella pneumoniae) - STRING interaction network
"cyaY" - Protein CyaY in Klebsiella pneumoniae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cyaYProtein CyaY; Iron-dependent inhibitor of iron-sulfur cluster formation; iron-binding and oxidizing protein; defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; Derived by automated computational analysis using gene prediction method- Protein Homology (106 aa)    
Predicted Functional Partners:
hscB
Co-chaperone protein HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (171 aa)
   
   
  0.890
hscA
Chaperone protein HscA; Involved in the maturation of iron-sulfur cluster-containing proteins; Derived by automated computational analysis using gene prediction method- Protein Homology (616 aa)
   
 
 
  0.859
JG24_18830
Iron-sulfur cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (128 aa)
   
 
  0.841
JG24_18810
Ferredoxin, 2Fe-2S; Derived by automated computational analysis using gene prediction method- Protein Homology (111 aa)
   
   
  0.795
JG24_16675
Derived by automated computational analysis using gene prediction method- Protein Homology (279 aa)
   
 
  0.781
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily (404 aa)
   
 
  0.723
JG24_26545
YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; Derived by automated computational analysis using gene prediction method- Protein Homology (238 aa)
 
        0.684
hemC
Transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (313 aa)
   
   
  0.682
dapF
Involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; Derived by automated computational analysis using gene prediction method- Protein Homology (274 aa)
   
        0.641
JG24_26525
Putative lipoprotein; Derived by automated computational analysis using gene prediction method- Protein Homology (67 aa)
              0.636
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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