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birA protein (Klebsiella pneumoniae) - STRING interaction network
"birA" - Bifunctional ligase/repressor BirA in Klebsiella pneumoniae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
birABifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5’-adenylate (BirA-bio- 5’-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (320 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family (346 aa)
   
 
  0.969
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation (342 aa)
   
   
  0.957
JG24_24490
Biotin sulfoxide reductase / Free methionine-(S)-sulfoxide reductase; Catalyzes the reduction of trimethylamine-N-oxide to form trimethylamine; Derived by automated computational analysis using gene prediction method- Protein Homology (776 aa)
       
    0.901
JG24_05625
Derived by automated computational analysis using gene prediction method- Protein Homology (769 aa)
       
    0.901
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily (677 aa)
 
 
  0.882
nrdR
Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (149 aa)
 
     
  0.857
JG24_23075
Catalyzes the formation of pyruvate from oxaloacetate; Derived by automated computational analysis using gene prediction method- Protein Homology (589 aa)
 
 
 
  0.850
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis (78 aa)
         
  0.835
JG24_18715
Inosine-5’-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method- Protein Homology (488 aa)
 
     
  0.814
JG24_21385
Catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the AdoMet synthase family (384 aa)
         
  0.812
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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