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JG24_27195 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_27195" - Replicative DNA helicase in Klebsiella pneumoniae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
JG24_27195Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins (471 aa)    
Predicted Functional Partners:
dnaG
DNA primase; Synthesizes RNA primers at the replication forks; Derived by automated computational analysis using gene prediction method- Protein Homology (581 aa)
 
 
  0.945
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box)- 5’-TTATC[CA]A[CA]A-3’. DnaA binds to ATP and to acidic phospholipids (467 aa)
 
 
  0.929
JG24_29345
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3’ invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA’s homology-searching function (460 aa)
 
   
  0.892
JG24_04535
DNA polymerase III subunits gamma and tau; Catalyzes the DNA-template-directed extension of the 3’-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta’ subunits to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method- Protein Homology (635 aa)
 
 
  0.834
JG24_29175
DNA replication protein DnaC; Acts to load the DnaB helicase onto the initiation site during DNA replication; Derived by automated computational analysis using gene prediction method- Protein Homology (245 aa)
 
 
 
  0.833
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
 
   
  0.823
murJ
Probable lipid II flippase MurJ; Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (511 aa)
 
   
  0.814
dnaE
DNA-directed DNA polymerase; Catalyzes DNA-template-directed extension of the 3’- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method- Protein Homology (1160 aa)
 
   
  0.808
alr
Alanine racemase, biosynthetic; Converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; Derived by automated computational analysis using gene prediction method- Protein Homology (359 aa)
 
   
  0.797
JG24_28045
Binds single-stranded DNA at the primosome assembly site; Derived by automated computational analysis using gene prediction method- Protein Homology (104 aa)
     
 
  0.778
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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