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JG24_29280 protein (Klebsiella pneumoniae) - STRING interaction network
"JG24_29280" - Manganese-dependent 5'-nucleotidase in Klebsiella pneumoniae
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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JG24_29280Manganese-dependent 5’-nucleotidase; specific for 5’-UMP, 5’-dUMP, and 5’-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; Derived by automated computational analysis using gene prediction method- Protein Homology (225 aa)    
Predicted Functional Partners:
cpdB
2’,3’-cyclic-nucleotide 2’-phosphodiesterase; Periplasmic enzyme; functions during ribonucleic acid degradation; 2’,3’-cyclic nucleotides are first converted to 3’-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the 5’-nucleotidase family (647 aa)
 
   
  0.942
JG24_04565
Inosine-guanosine kinase; Catalyzes the formation of inosine/guanosine monophosphate from inosine or guanosine and ATP; Derived by automated computational analysis using gene prediction method- Protein Homology (434 aa)
   
   
    0.937
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis (294 aa)
 
   
  0.926
JG24_26625
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family (253 aa)
   
   
  0.924
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (264 aa)
       
  0.922
deoD
Purine-nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2’- deoxyribonucleosides to the free base and (2’-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
   
   
  0.922
deoA
Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family (440 aa)
         
  0.919
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (213 aa)
   
 
  0.916
dgt
dGTPase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs (504 aa)
       
  0.915
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (208 aa)
       
  0.913
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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