STRINGSTRING
serB protein (Klebsiella pneumoniae) - STRING interaction network
"serB" - Phosphoserine phosphatase in Klebsiella pneumoniae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
serBPhosphoserine phosphatase; Catalyzes the formation of serine from O-phosphoserine; Derived by automated computational analysis using gene prediction method- Protein Homology (323 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (362 aa)
   
 
  0.974
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
  0.961
JG24_20265
L-serine dehydratase; Catalyzes the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method- Protein Homology (455 aa)
         
  0.955
JG24_15710
L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Catalyzes the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method- Protein Homology (454 aa)
         
  0.955
JG24_29345
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3’ invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA’s homology-searching function (460 aa)
 
      0.938
JG24_21515
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method- Protein Homology (456 aa)
     
 
  0.907
ilvA
L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (514 aa)
     
 
  0.903
JG24_15450
Threonine dehydratase, catabolic; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method- Protein Homology (329 aa)
     
 
  0.903
JG24_09505
Catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; Derived by automated computational analysis using gene prediction method- Protein Homology (397 aa)
   
 
    0.902
JG24_09500
Tryptophan synthase alpha chain; Derived by automated computational analysis using gene prediction method- Protein Homology (269 aa)
     
 
    0.901
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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