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leuO protein (Klebsiella pneumoniae) - STRING interaction network
"leuO" - Activator for leuABCD operon in Klebsiella pneumoniae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
leuOActivator for leuABCD operon; member of LysR family of transcriptional activators; Derived by automated computational analysis using gene prediction method- Protein Homology (316 aa)    
Predicted Functional Partners:
slyA
Transcriptional regulator SlyA; Transcription regulator that can specifically activate or repress expression of target genes (146 aa)
           
  0.583
ompR
Part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
       
 
  0.554
JG24_23815
Uncharacterized protein; May function as a transcriptional regulator that controls feoABC expression (79 aa)
   
          0.462
nhaR
Transcriptional activator NhaR; Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; Derived by automated computational analysis using gene prediction method- Protein Homology (298 aa)
   
          0.444
JG24_03135
Copper homeostasis protein CutF / Lipoprotein NlpE involeved in surface adhesion; Derived by automated computational analysis using gene prediction method- Protein Homology (239 aa)
   
          0.442
envZ
Membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method- Protein Homology (451 aa)
           
  0.420
JG24_29215
Transcriptional activator protein bglJ; Derived by automated computational analysis using gene prediction method- Protein Homology (224 aa)
   
     
  0.420
JG24_08015
Inner membrane protein YcdZ; Derived by automated computational analysis using gene prediction method- Protein Homology (160 aa)
   
          0.404
JG24_10265
Heat shock protein hslJ; Derived by automated computational analysis using gene prediction method- Protein Homology (146 aa)
   
          0.400
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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