STRINGSTRING
ftsZ protein (Klebsiella pneumoniae) - STRING interaction network
"ftsZ" - Cell division protein FtsZ in Klebsiella pneumoniae
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (383 aa)    
Predicted Functional Partners:
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring; Belongs to the FtsA/MreB family (420 aa)
 
  0.996
JG24_18300
Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins (351 aa)
     
 
  0.961
ftsQ
Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (276 aa)
   
 
  0.922
minC
Probable septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (233 aa)
   
 
 
  0.916
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family (491 aa)
   
 
  0.909
slmA
Transcriptional regulator SlmA, TetR family; FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; Derived by automated computational analysis using gene prediction method- Protein Homology (198 aa)
       
 
  0.909
ftsW
Probable peptidoglycan glycosyltransferase FtsW; Peptidoglycan polymerase that is essential for cell division; Belongs to the SEDS family. FtsW subfamily (424 aa)
 
   
  0.895
sulA
Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1-1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (169 aa)
       
 
  0.889
murG
UDP-diphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; N-acetylglucosaminyl transferase; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; Derived by automated computational analysis using gene prediction method- Protein Homology (356 aa)
 
 
  0.882
JG24_20555
Derived by automated computational analysis using gene prediction method- Protein Homology (610 aa)
   
 
  0.876
Your Current Organism:
Klebsiella pneumoniae
NCBI taxonomy Id: 573
Other names: ATCC 13883, Bacillus pneumoniae, Bacterium pneumoniae crouposae, CCUG 225, CIP 82.91, DSM 30104, HAMBI 450, Hyalococcus pneumoniae, IFO 14940, K. pneumoniae, Klebsiella pneumoniae, Klebsiella sp. M-AI-2, Klebsiella sp. PB12, Klebsiella sp. RCE-7, LMG 2095, NBRC 14940, NCTC 9633
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