node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACV24183.1 | psmA | Mefer_0348 | Mefer_1376 | PFAM: protein of unknown function DUF75. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.888 |
ACV24183.1 | psmB | Mefer_0348 | Mefer_0382 | PFAM: protein of unknown function DUF75. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.695 |
ACV24217.1 | proS | Mefer_0383 | Mefer_0381 | KEGG: zgc:110671; K01172; TIGRFAM: KH-domain/beta-lactamase-domain protein; PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; SMART: KH domain protein. | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | 0.429 |
ACV24217.1 | psmB | Mefer_0383 | Mefer_0382 | KEGG: zgc:110671; K01172; TIGRFAM: KH-domain/beta-lactamase-domain protein; PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; SMART: KH domain protein. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.738 |
ACV24570.1 | pan | Mefer_0752 | Mefer_0150 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.765 |
ACV24570.1 | proS | Mefer_0752 | Mefer_0381 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | 0.490 |
ACV24570.1 | psmA | Mefer_0752 | Mefer_1376 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.845 |
ACV24570.1 | psmB | Mefer_0752 | Mefer_0382 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.830 |
ACV24570.1 | rpl40e | Mefer_0752 | Mefer_1082 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.969 |
ACV24976.1 | psmA | Mefer_1167 | Mefer_1376 | KEGG: gsu:GSU3379 aIF-2BI family translation initiation factor; TIGRFAM: translation initiation factor, aIF-2BII family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related; Belongs to the eIF-2B alpha/beta/delta subunits family. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.633 |
ACV24976.1 | psmB | Mefer_1167 | Mefer_0382 | KEGG: gsu:GSU3379 aIF-2BI family translation initiation factor; TIGRFAM: translation initiation factor, aIF-2BII family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related; Belongs to the eIF-2B alpha/beta/delta subunits family. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.640 |
mtrA | mtrA-2 | Mefer_0943 | Mefer_0944 | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | 0.969 |
mtrA | psmB | Mefer_0943 | Mefer_0382 | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.667 |
mtrA-2 | mtrA | Mefer_0944 | Mefer_0943 | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | 0.969 |
mtrA-2 | psmB | Mefer_0944 | Mefer_0382 | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.667 |
pan | ACV24570.1 | Mefer_0150 | Mefer_0752 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | 0.765 |
pan | psmA | Mefer_0150 | Mefer_1376 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.995 |
pan | psmB | Mefer_0150 | Mefer_0382 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.994 |
pan | rpl40e | Mefer_0150 | Mefer_1082 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.970 |
proS | ACV24217.1 | Mefer_0381 | Mefer_0383 | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | KEGG: zgc:110671; K01172; TIGRFAM: KH-domain/beta-lactamase-domain protein; PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; SMART: KH domain protein. | 0.429 |