Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV24615.1PFAM: nitrite and sulphite reductase 4Fe-4S region; 4Fe-4S ferredoxin iron-sulfur binding domain protein; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: gur:Gura_3941 nitrite and sulphite reductase 4Fe-4S region. (271 aa)    
Predicted Functional Partners:
ACV24388.1
PFAM: pyridine nucleotide-disulphide oxidoreductase dimerization region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: afw:Anae109_0766 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
   
 0.921
ACV24614.1
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: ftf:FTF0287c hypothetical protein.
       0.773
ACV24616.1
TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: cvi:CV_1562 precorrin-3B C17-methyltransferase.
       0.752
ACV24617.1
Cellulase; PFAM: peptidase M42 family protein; peptidase M20; KEGG: ecg:E2348C_4202 putative fructose-specific phosphotransferase system protein FrvX.
       0.558
ACV24667.1
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dal:Dalk_4009 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
   
 0.426
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (14%) [HD]