node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACV24126.1 | ACV25188.1 | Mefer_0290 | Mefer_1381 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | PFAM: Protein of unknown function DUF2144. | 0.719 |
ACV24126.1 | thi4 | Mefer_0290 | Mefer_1385 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.602 |
ACV24126.1 | topA | Mefer_0290 | Mefer_0728 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.546 |
ACV24269.1 | thi4 | Mefer_0443 | Mefer_1385 | PFAM: Phosphomethylpyrimidine kinase; Phosphomethylpyrimidine kinase type-1; KEGG: ecn:Ecaj_0192 phosphomethylpyrimidine kinase. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.880 |
ACV24269.1 | thiC | Mefer_0443 | Mefer_0126 | PFAM: Phosphomethylpyrimidine kinase; Phosphomethylpyrimidine kinase type-1; KEGG: ecn:Ecaj_0192 phosphomethylpyrimidine kinase. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.997 |
ACV25187.1 | ACV25188.1 | Mefer_1380 | Mefer_1381 | Brix domain protein; Probably involved in the biogenesis of the ribosome. | PFAM: Protein of unknown function DUF2144. | 0.981 |
ACV25187.1 | ACV25190.1 | Mefer_1380 | Mefer_1383 | Brix domain protein; Probably involved in the biogenesis of the ribosome. | KEGG: rpr:RP083 hypothetical protein. | 0.719 |
ACV25187.1 | ACV25191.1 | Mefer_1380 | Mefer_1384 | Brix domain protein; Probably involved in the biogenesis of the ribosome. | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dat:HRM2_15240 BioB2. | 0.785 |
ACV25187.1 | rpl18a | Mefer_1380 | Mefer_1382 | Brix domain protein; Probably involved in the biogenesis of the ribosome. | PFAM: Ribosomal LX protein. | 0.996 |
ACV25187.1 | rpoP | Mefer_1380 | Mefer_1379 | Brix domain protein; Probably involved in the biogenesis of the ribosome. | RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. | 0.990 |
ACV25187.1 | thi4 | Mefer_1380 | Mefer_1385 | Brix domain protein; Probably involved in the biogenesis of the ribosome. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.511 |
ACV25188.1 | ACV24126.1 | Mefer_1381 | Mefer_0290 | PFAM: Protein of unknown function DUF2144. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | 0.719 |
ACV25188.1 | ACV25187.1 | Mefer_1381 | Mefer_1380 | PFAM: Protein of unknown function DUF2144. | Brix domain protein; Probably involved in the biogenesis of the ribosome. | 0.981 |
ACV25188.1 | ACV25190.1 | Mefer_1381 | Mefer_1383 | PFAM: Protein of unknown function DUF2144. | KEGG: rpr:RP083 hypothetical protein. | 0.734 |
ACV25188.1 | ACV25191.1 | Mefer_1381 | Mefer_1384 | PFAM: Protein of unknown function DUF2144. | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dat:HRM2_15240 BioB2. | 0.734 |
ACV25188.1 | rpl18a | Mefer_1381 | Mefer_1382 | PFAM: Protein of unknown function DUF2144. | PFAM: Ribosomal LX protein. | 0.975 |
ACV25188.1 | rpoP | Mefer_1381 | Mefer_1379 | PFAM: Protein of unknown function DUF2144. | RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. | 0.997 |
ACV25188.1 | thi4 | Mefer_1381 | Mefer_1385 | PFAM: Protein of unknown function DUF2144. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.536 |
ACV25190.1 | ACV25187.1 | Mefer_1383 | Mefer_1380 | KEGG: rpr:RP083 hypothetical protein. | Brix domain protein; Probably involved in the biogenesis of the ribosome. | 0.719 |
ACV25190.1 | ACV25188.1 | Mefer_1383 | Mefer_1381 | KEGG: rpr:RP083 hypothetical protein. | PFAM: Protein of unknown function DUF2144. | 0.734 |