node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADL11756.1 | ADL11757.1 | Acear_0205 | Acear_0206 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 0.998 |
ADL11756.1 | ADL11762.1 | Acear_0205 | Acear_0211 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR019818:IPR001804; KEGG: hor:Hore_10890 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: B8CX24 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase. | 0.973 |
ADL11756.1 | ADL11763.1 | Acear_0205 | Acear_0212 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR002034:IPR000891:IPR013709:IPR013785:IPR 005675; KEGG: pfu:PF0941 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; SPTR: Q8U298 Leua homolog alpha-isopropylmalate synthase related; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to [...] | 0.926 |
ADL11756.1 | ADL12178.1 | Acear_0205 | Acear_0636 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TP [...] | 0.901 |
ADL11756.1 | ADL12179.1 | Acear_0205 | Acear_0637 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mma:MM_0669 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8PZ25 Acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 0.994 |
ADL11756.1 | ilvC | Acear_0205 | Acear_0207 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.996 |
ADL11756.1 | ilvD | Acear_0205 | Acear_0204 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR020558:IPR000581:IPR004404; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C7HB79 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.900 |
ADL11756.1 | leuA | Acear_0205 | Acear_0208 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.949 |
ADL11756.1 | leuC | Acear_0205 | Acear_0209 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.733 |
ADL11756.1 | leuD | Acear_0205 | Acear_0210 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.803 |
ADL11757.1 | ADL11756.1 | Acear_0206 | Acear_0205 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] | 0.998 |
ADL11757.1 | ADL11762.1 | Acear_0206 | Acear_0211 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR019818:IPR001804; KEGG: hor:Hore_10890 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: B8CX24 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase. | 0.977 |
ADL11757.1 | ADL11763.1 | Acear_0206 | Acear_0212 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR002034:IPR000891:IPR013709:IPR013785:IPR 005675; KEGG: pfu:PF0941 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; SPTR: Q8U298 Leua homolog alpha-isopropylmalate synthase related; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to [...] | 0.945 |
ADL11757.1 | ADL12178.1 | Acear_0206 | Acear_0636 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TP [...] | 0.994 |
ADL11757.1 | ADL12179.1 | Acear_0206 | Acear_0637 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mma:MM_0669 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8PZ25 Acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 0.901 |
ADL11757.1 | ilvC | Acear_0206 | Acear_0207 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
ADL11757.1 | ilvD | Acear_0206 | Acear_0204 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR020558:IPR000581:IPR004404; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C7HB79 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.654 |
ADL11757.1 | leuA | Acear_0206 | Acear_0208 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.950 |
ADL11757.1 | leuC | Acear_0206 | Acear_0209 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.865 |
ADL11757.1 | leuD | Acear_0206 | Acear_0210 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.875 |