STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Coexpression
Experiments
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[Homology]
Score
ADL12553.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (122 aa)    
Predicted Functional Partners:
ADL12556.1
COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099:IPR016040:IPR002912; KEGG: hmo:HM1_1926 prephenate dehydrogenase, putative; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydrogenase; SPTR: B0TFQ3 Prephenate dehydrogenase, putative; PFAM: Prephenate dehydrogenase; ACT domain.
  
 
  0.978
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.951
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR003136:IPR000623:IPR011994; KEGG: bay:RBAM_021040 cytidylate kinase; PFAM: cytidylate kinase region; shikimate kinase; SPTR: A3F449 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
      0.941
trpE
Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
    
  0.904
ADL12594.1
COGs: COG4492 ACT domain-containing protein; InterPro IPR008310:IPR002912; KEGG: dhd:Dhaf_3377 amino acid-binding ACT domain protein; PFAM: amino acid-binding ACT domain protein; SPTR: A1HTV0 Amino acid-binding ACT domain protein; Belongs to the UPF0735 family.
     
  0.900
ADL13789.1
Glutamine amidotransferase of anthranilate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR017926:IPR006220:IPR011702:IPR001317:IPR 000991:IPR006221; KEGG: mei:Msip34_2513 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: C6J5A9 Glutamine amidotransferase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
    
  0.819
mqnA
Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
    
  0.808
ADL12552.1
HutP family protein; InterPro IPR015111; KEGG: pth:PTH_1631 hypothetical protein; PFAM: HutP family protein; SPTR: A5D1T0 Putative uncharacterized protein; PFAM: HutP.
       0.794
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR005861:IPR015424:IPR004839:IPR001176:IPR 015421; KEGG: mta:Moth_0515 histidinol phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
    0.787
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
    0.770
Your Current Organism:
Acetohalobium arabaticum
NCBI taxonomy Id: 574087
Other names: A. arabaticum DSM 5501, Acetohalobium arabaticum DSM 5501, Acetohalobium arabaticum str. DSM 5501, Acetohalobium arabaticum strain DSM 5501
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