STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1288COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160: IPR001261; KEGG: plm:Plim_1868 retinal dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Retinal dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (489 aa)    
Predicted Functional Partners:
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.939
Isop_2345
COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814: IPR004636; KEGG: cyc:PCC7424_4452 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine transaminase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.931
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
  
 
 0.916
Isop_1529
6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: hoh:Hoch_3369 6-phosphogluconate dehydrogenase NAD-binding protein; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 3-hydroxyisobutyrate dehydrogenase; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase.
  
 
 0.915
Isop_3556
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: psl:Psta_1855 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.915
Isop_0422
Alcohol dehydrogenase GroES domain protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154: IPR013149: IPR002328; KEGG: rca:Rcas_4434 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: Alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase.
 
 
 0.912
panD
L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
     
 0.903
Isop_1441
COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: mta:Moth_0404 glycerate kinase; PFAM: glycerate kinase; PRIAM: Glycerate kinase; SPTR: Glycerate kinase; TIGRFAM: glycerate kinase; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family.
   
 
 0.901
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
     
 0.900
Isop_1630
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR012408: IPR015590; KEGG: plm:Plim_1751 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Ethanolamine utilization protein EutE; PFAM: Aldehyde dehydrogenase family.
     
  0.900
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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