node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VS_0388 | VS_0389 | VS_0388 | VS_0389 | Acetolactate synthase isozyme III large subunit. | Acetolactate synthase isozyme III small subunit. | 0.999 |
VS_0388 | VS_0485 | VS_0388 | VS_0485 | Acetolactate synthase isozyme III large subunit. | Threonine synthase. | 0.481 |
VS_0388 | VS_2569 | VS_0388 | VS_2569 | Acetolactate synthase isozyme III large subunit. | Oxaloacetate decarboxylase alpha chain. | 0.804 |
VS_0388 | VS_3143 | VS_0388 | VS_3143 | Acetolactate synthase isozyme III large subunit. | Acetolactate synthase isozyme II large subunit. | 0.697 |
VS_0388 | ilvC | VS_0388 | VS_0061 | Acetolactate synthase isozyme III large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.974 |
VS_0388 | ilvD | VS_0388 | VS_3146 | Acetolactate synthase isozyme III large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.950 |
VS_0388 | leuA | VS_0388 | VS_0380 | Acetolactate synthase isozyme III large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.952 |
VS_0388 | leuB | VS_0388 | VS_0379 | Acetolactate synthase isozyme III large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.957 |
VS_0388 | leuC | VS_0388 | VS_0378 | Acetolactate synthase isozyme III large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.927 |
VS_0388 | leuD | VS_0388 | VS_0377 | Acetolactate synthase isozyme III large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.935 |
VS_0389 | VS_0388 | VS_0389 | VS_0388 | Acetolactate synthase isozyme III small subunit. | Acetolactate synthase isozyme III large subunit. | 0.999 |
VS_0389 | VS_0485 | VS_0389 | VS_0485 | Acetolactate synthase isozyme III small subunit. | Threonine synthase. | 0.717 |
VS_0389 | VS_2569 | VS_0389 | VS_2569 | Acetolactate synthase isozyme III small subunit. | Oxaloacetate decarboxylase alpha chain. | 0.800 |
VS_0389 | VS_3143 | VS_0389 | VS_3143 | Acetolactate synthase isozyme III small subunit. | Acetolactate synthase isozyme II large subunit. | 0.998 |
VS_0389 | ilvC | VS_0389 | VS_0061 | Acetolactate synthase isozyme III small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
VS_0389 | ilvD | VS_0389 | VS_3146 | Acetolactate synthase isozyme III small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.934 |
VS_0389 | leuA | VS_0389 | VS_0380 | Acetolactate synthase isozyme III small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.965 |
VS_0389 | leuB | VS_0389 | VS_0379 | Acetolactate synthase isozyme III small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.983 |
VS_0389 | leuC | VS_0389 | VS_0378 | Acetolactate synthase isozyme III small subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.934 |
VS_0389 | leuD | VS_0389 | VS_0377 | Acetolactate synthase isozyme III small subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.958 |